Thus, urolithin A, the end-products of both ellagitannins and ellagic acid, extends lifespan and improves fitness during C. elegans aging and improves muscle function and exercise capacity in rodents. Mc Cormack B, Maenhoudt N, Fincke V, Stejskalova A, Greve B, Kiesel L, et al. Published online: 01 Jun 2022. In addition, plasma hippuric acid, a glycine conjugate of benzoic acid, both metabolites present in Mankai, was significantly associated with VAT reduction even after controlling for WC change. Polyphenols can also detoxify gut metabolites and repress the growth of pathogenic bacteria, such as Clostridium perfringens, Clostridium difficile and Bacteroides spp. Denk et al. Espn JC, Larrosa M, Garca-Conesa MT, et al. Taninos hidrolizables; bioqumica, aspectos nutricionales y analticos y efectos en la salud. Denk et al. In our trial, elevated urolithin A was correlated with walnut and Mankai consumption, as its precursor, ellagic acid , was found in both. Jose Alberto Lpez-Daz 1, Emilio lvarez-Parrilla 1, Laura A. de la Rosa 1 y Arnulfo Ramos-Jimenez 1 The aim of this study was to investigate the synergistic effects and mechanisms of supplementation with the probiotic Weizmannia coagulans (W. coagulans) on the prevention of insulin resistance by EA; Another dietary polyphenol such as ellagic acid and ellagitannins are transformed into urolithin A (an anti-inflammatory metabolite) by Gordonibacter spp. Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway. Nutr Hosp. In addition, plasma hippuric acid, a glycine conjugate of benzoic acid, both metabolites present in Mankai, was significantly associated with VAT reduction even after controlling for WC change. Jose Alberto Lpez-Daz 1, Emilio lvarez-Parrilla 1, Laura A. de la Rosa 1 y Arnulfo Ramos-Jimenez 1 Ellagitannins (the main polyphenols in pomegranate juice) are hydrolyzed to ellagic acid, and then to urolithin A (UA) derivatives. Pages: 1047-1054. Francisco Javier Olivas-Aguirre 1, Abraham Wall-Medrano 1, Gustavo A. Gonzlez-Aguilar 2, . Polyphenols can also detoxify gut metabolites and repress the growth of pathogenic bacteria, such as Clostridium perfringens, Clostridium difficile and Bacteroides spp. According to a tissue distribution experiment in wild-type mice, the prostate gland rapidly takes up high concentrations of UA after oral or intraperitoneal administration (0.3 mg/mouse/dose). Various parts of the tree and fruit are used to make medicine. Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. 2021;36:150119. show that Urolithin A, a natural metabolite of pomegranate extract, enhances antigen presentation in cancer and promotes mitophagy in CD8+ T cells, resulting in generation regenerative stem cell-like memory (TSCM) cells with enhanced anti-tumor properties. Revisin. Ellagitannins (the main polyphenols in pomegranate juice) are hydrolyzed to ellagic acid, and then to urolithin A (UA) derivatives. 2015;31(1):55-66 ISSN 0212-1611 CODEN NUHOEQ S.V.R. Among the various metabolites, Urolithin-A was found to be more dynamic by hindering the synthesis of Yuandi Lei, Tianyi Jiang, Liqin He, Yanping Liu, Zhanbing Sun, Weihua Deng, Lian Huang & Zhaohui Zhang. Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. Espn JC, Larrosa M, Garca-Conesa MT, et al. The aim of this study was to investigate the synergistic effects and mechanisms of supplementation with the probiotic Weizmannia coagulans (W. coagulans) on the prevention of insulin resistance by EA; Revisin. Urolithin B is one of the four metabolites of the Ellagic Acid/Ellagitannins family. Francisco Javier Olivas-Aguirre 1, Abraham Wall-Medrano 1, Gustavo A. Gonzlez-Aguilar 2, . Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats. Article Google Scholar This mechanism led us to test Urolithin A, a common metabolite that promotes mitophagy and extends lifespan in C. elegans, as a possible therapeutic to delay reproductive decline. Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. 2021;36:150119. The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging. . Studies suggest that the ellagic acid-rich fractions and metabolites of pomegranate urolithin-A provide a protective effect against colitis . The ellagitannins (ellagic acids) are metabolised to urolithins that are circulated in the plasma of consumers, thereby increasing the counts of bifidobacteria and lactobacilli. In-depth analysis demonstrates that mitophagy is required for the beneficial effect of urolithin A (Ryu et al., 2016). [ 70 ]. . Zhou B. Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose. It is a type of phenolic compound that is produced in the human gut after absorption of ellagitannin containing foods such as pomegranate, strawberries, Hum Reprod. Hum Reprod. Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. Another dietary polyphenol such as ellagic acid and ellagitannins are transformed into urolithin A (an anti-inflammatory metabolite) by Gordonibacter spp. In-depth analysis demonstrates that mitophagy is required for the beneficial effect of urolithin A (Ryu et al., 2016). In our trial, elevated urolithin A was correlated with walnut and Mankai consumption, as its precursor, ellagic acid , was found in both. Urolithin B is one of the four metabolites of the Ellagic Acid/Ellagitannins family. Studies suggest that the ellagic acid-rich fractions and metabolites of pomegranate urolithin-A provide a protective effect against colitis . 318. Various parts of the tree and fruit are used to make medicine. Published online: 01 Jun 2022. . Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. Crossref | PubMed | ISI | Google Scholar; 22. Urolithin B is one of the four metabolites of the Ellagic Acid/Ellagitannins family. . Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. (1) Background: Ellagic acid (EA) acts as a product of gut microbiota transformation to prevent insulin resistance, which is limited by high-fat diet (HFD)-induced dysbiosis. 9 , 41004106 (2018). Crossref | PubMed | ISI | Google Scholar; 22. The ellagic acid metabolites urolithin A and B differentially affect growth, adhesion, motility, and invasion of endometriotic cells in vitro. This mechanism led us to test Urolithin A, a common metabolite that promotes mitophagy and extends lifespan in C. elegans, as a possible therapeutic to delay reproductive decline. Published online: 01 Jun 2022. According to a tissue distribution experiment in wild-type mice, the prostate gland rapidly takes up high concentrations of UA after oral or intraperitoneal administration (0.3 mg/mouse/dose). Article PubMed Google Scholar Pages: 1047-1054. It belongs to the class of organic compounds known as benzo-coumarins or dibenzo--pyrones.Its precursors ellagic acids and ellagitannins are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. Article Google Scholar In our trial, elevated urolithin A was correlated with walnut and Mankai consumption, as its precursor, ellagic acid , was found in both. Urolithin A, a metabolite compound resulting from the transformation of ellagitannins by gut bacteria, has been reported to have anti-oxidant, anti-inflammatory, and anti-apoptotic properties. . Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. The ellagitannins (ellagic acids) are metabolised to urolithins that are circulated in the plasma of consumers, thereby increasing the counts of bifidobacteria and lactobacilli. Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. Nutr Hosp. Urolithin A Attenuates Helicobacter pylori-Induced Damage In Vivo. Crossref | PubMed | ISI | Google Scholar; 22. [ 70 ]. Food Funct. Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway. Pages: 1047-1054. Pomegranate is a tree. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. In-depth analysis demonstrates that mitophagy is required for the beneficial effect of urolithin A (Ryu et al., 2016). Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway. Urolithin A, a metabolite compound resulting from the transformation of ellagitannins by gut bacteria, has been reported to have anti-oxidant, anti-inflammatory, and anti-apoptotic properties. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. 318. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. The Phoenix dactylifera extract led to attenuated cardiotoxicity and nephrotoxicity secondary to decreased oxidative stress and apoptotic pressure. . Studies suggest that the ellagic acid-rich fractions and metabolites of pomegranate urolithin-A provide a protective effect against colitis . Francisco Javier Olivas-Aguirre 1, Abraham Wall-Medrano 1, Gustavo A. Gonzlez-Aguilar 2, . Thus, urolithin A, the end-products of both ellagitannins and ellagic acid, extends lifespan and improves fitness during C. elegans aging and improves muscle function and exercise capacity in rodents. Yuandi Lei, Tianyi Jiang, Liqin He, Yanping Liu, Zhanbing Sun, Weihua Deng, Lian Huang & Zhaohui Zhang. Denk et al. Article PubMed Google Scholar Zhou B. Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose. Pomegranate is a tree. . It is a type of phenolic compound that is produced in the human gut after absorption of ellagitannin containing foods such as pomegranate, strawberries, Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria. The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging. (1) Background: Ellagic acid (EA) acts as a product of gut microbiota transformation to prevent insulin resistance, which is limited by high-fat diet (HFD)-induced dysbiosis. Interestingly, Phoenix dactylifera extract (including gallic acid, coffeic acid, and ellagic acid phytochemicals) increased cardiac and kidney PD-1 expressions in a mouse model exposed to Adriamycin .